I was thinking about the dramatic effect that dexamethasone had on my wife's ALS symptoms on several occasions and it occurred to me that there must be several non-prescription drugs and supplements that could help tame the neuro-inflammation of ALS. After a quick search, I came up with the following: Pomegranate juice, ginger root or extract, Lunasin (soy peptides), zinc gluconate, turmeric, marijuana, alcohol, vitamin D3, ibuprofen, dextromethorphan and last, but not least, Naproxen (Aleve). Most of these products are easily obtainable in most countries. Dextromethorphan is used in over-the-counter cough syrup and is known to have strong anti-inflammatory and thus neuroprotective properties. Soy peptides can be ordered online.
Naproxen is particularly interesting because it inhibits the prostaglandin E2 hormones and pro-inflammatory cytokines that are known to be elevated in ALS patients. I would be interested in knowing about the experiences of ALS patients out there who might have experimented with a high dose (2000 mg or more per day) of Naproxen for a few days. I suspect it might have a noticeably positive effect on some patients. To anyone who may want to experiment with Naproxen, I would also recommend taking some L-arginine and magnesium during the treatment to help dilate the arteries and capillaries. This should make it easier for the drug to reach difficult areas of the brain and spinal cord. Of course, if you do get improvements from a high dose of naproxen, it goes without saying that something more powerful like dexamethasone could do wonders. I'm a little excited about the potential of Naproxen because it is an easily obtainable drug. If it did cause improvements in ALS symptoms, it would send a powerful message because a lot of people can try it at home without a prescription.
Anesthetics and Glucocorticoids for ALS
Naproxen Reduces Excitotoxic Neurodegeneration in Vivo